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Chem Commun (Camb). 2006 Jun 14;(22):2332-4. Epub 2006 Apr 13.

The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's beta-amyloid polypeptide.

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  • 1Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, N-0315, Oslo, Norway. c.h.gorbitz@kjemi.uio.no

Abstract

Alzheimer's beta-amyloid diphenylalanine motif has previously been shown to self-assemble into discrete and extraordinary stiff nanotubes; these nanotubes were initially thought to be distinct from the single crystal structure of diphenylalanine, but it is now shown that the X-ray powder diffraction pattern of the nanotubes is identical to the simulated pattern for the single crystal structure, affording a new foundation for understanding and rationalizing the properties of this remarkable organic material.

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