Format

Send to

Choose Destination
PLoS Pathog. 2006 May;2(5):e42.

Crossing the line: selection and evolution of virulence traits.

Author information

1
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.

Abstract

The evolution of pathogens presents a paradox. Pathogenic species are often absolutely dependent on their host species for their propagation through evolutionary time, yet the pathogenic lifestyle requires that the host be damaged during this dependence. It is clear that pathogenic strategies are successful in evolutionary terms because a diverse array of pathogens exists in nature. Pathogens also evolve using a broad range of molecular mechanisms to acquire and modulate existing virulence traits in order to achieve this success. Detailing the benefit of enhanced selection derived through virulence and understanding the mechanisms through which virulence evolves are important to understanding the natural world and both have implications for human health.

PMID:
16733541
PMCID:
PMC1464392
DOI:
10.1371/journal.ppat.0020042
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center