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Planta Med. 2006 Aug;72(10):935-8. Epub 2006 May 29.

A new cytotoxic amide from the stem wood of Hibiscus tiliaceus.

Author information

1
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan, ROC.

Abstract

A new coumarin, hibiscusin, and a new amide, hibiscusamide, together with eleven known compounds including vanillic acid, P-hydroxybenzoic acid, syringic acid, P-hydroxybenzaldehyde, scopoletin, N- trans-feruloyltyramine, N-cis-feruloyltyramine, a mixture of beta-sitosterol and stigmasterol, a mixture of beta-sitostenone and stigmasta-4,22-dien-3-one were isolated from the stem wood of Hibiscus tiliaceus. The structures of these new compounds were determined through spectral analyses. Among the isolates, three compounds exhibited cytotoxicity (IC (50) values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro.

PMID:
16732539
DOI:
10.1055/s-2006-931604
[Indexed for MEDLINE]

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