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Nature. 1991 Apr 18;350(6319):585-9.

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development.

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1
European Molecular Biology Laboratory, Heidelberg, Germany.

Abstract

The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.

PMID:
1673231
DOI:
10.1038/350585a0
[Indexed for MEDLINE]
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