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Pediatr Infect Dis J. 2006 Jun;25(6):562-4.

Linezolid-resistant Staphylococcus aureus in two pediatric patients receiving low-dose linezolid therapy.

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Department of Laboratory Medicine, Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA.


We report 2 sisters with hyper-IgE syndrome treated with daily suppressive dosages of linezolid (LZD) who developed LZD-resistant Staphylococcus aureus carrying the G2576T mutation in the 23S rRNA gene. Molecular typing suggested transmission of the resistant strain from one sister to the other. LZD-susceptible S. aureus was isolated 2 months after LZD discontinuation. LZD-resistant S. aureus remains rare but may occur while receiving suppressive therapy.

[Indexed for MEDLINE]

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