Childhood empyema: limited potential impact of 7-valent pneumococcal conjugate vaccine

Margaret Fletcher; John Leeming; Keith Cartwright; Adam Finn; South West of England Invasive Community Acquired Infection Study Group

doi:10.1097/01.inf.0000219535.14201.1b

Childhood empyema: limited potential impact of 7-valent pneumococcal conjugate vaccine

Pediatr Infect Dis J. 2006 Jun;25(6):559-60. doi: 10.1097/01.inf.0000219535.14201.1b.

Authors

Margaret Fletcher¹, John Leeming, Keith Cartwright, Adam Finn; South West of England Invasive Community Acquired Infection Study Group

Affiliation

¹ Faculty of Health and Social Care, University of the West of England, Bristol, UK. Margaret.Fletcher@uwe.ac.uk

PMID: 16732158
DOI: 10.1097/01.inf.0000219535.14201.1b

Abstract

During 2003-2004, locally presenting pleural empyema cases in children increased 3-fold. Antigen analysis of empyema fluid identified Streptococcus pneumoniae in 27 of 29 cases for whom samples were available and capsular polysaccharide type 1 in 18 of these. Use of a conjugate vaccine without serotype 1 antigen would have had limited impact on this morbidity in our region.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Distribution
Antibodies, Bacterial / analysis
Child
Child, Preschool
Empyema, Pleural / epidemiology
Empyema, Pleural / microbiology
Empyema, Pleural / prevention & control*
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Immunity / physiology
Incidence
Male
Pneumococcal Infections / epidemiology
Pneumococcal Infections / prevention & control*
Pneumococcal Vaccines / administration & dosage*
Prospective Studies
Risk Assessment
Streptococcus pneumoniae / isolation & purification*
United Kingdom / epidemiology
Vaccines, Conjugate / administration & dosage

Substances

Antibodies, Bacterial
Pneumococcal Vaccines
Vaccines, Conjugate