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Bioorg Med Chem Lett. 2006 Aug 1;16(15):3955-9. Epub 2006 May 30.

Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.

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Institute of Medical Technology, University of Tampere, Tampere University Hospital, Biokatu 6, 33520 Tampere, Finland.


The first activation study of isoform XIII of carbonic anhydrase (CA, EC is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine type were included in the study. As for CA I and II, CA XIII activators enhance kcat and show no effect on KM, for the physiologic reaction catalyzed by this isoform. Excellent CA XIII activating properties were shown by D-amino acids (His, Phe, DOPA, and Trp), serotonin, and 4-(2-aminoethyl)-morpholine, whereas the corresponding L-amino acids, dopamine, histamine, and 1-(2-aminoethyl)-piperazine, were weaker activators.

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