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Trends Microbiol. 2006 Jul;14(7):289-91. Epub 2006 May 26.

Unexpected structure of Epstein-Barr virus lytic cycle activator Zta.

Author information

1
School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK. A.J.Sinclair@sussex.ac.uk

Abstract

The key viral gene responsible for initiating the replicative cycle of Epstein-Barr virus (EBV), termed BZLF1, encodes the multifunctional protein Zta (ZEBRA or Z). It interacts with DNA as both a transcription and a replication factor, modulates both intracellular signal transduction and the DNA-damage response and manipulates cell cycle progression. Muller and colleagues have resolved the structure of Zta bound to DNA, which confirms some structural predictions but reveals an unexpected twist and a complex dimerization interface. Because EBV is associated with human disease, Zta presents a prime target for drug design.

PMID:
16730442
PMCID:
PMC4221735
DOI:
10.1016/j.tim.2006.05.003
[Indexed for MEDLINE]
Free PMC Article

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