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Virol J. 2006 May 29;3:39.

In vitro inhibition of human influenza A virus replication by chloroquine.

Author information

1
Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, #09-01, 117510, Singapore. oengeong@dso.org.sg

Abstract

Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.

PMID:
16729896
PMCID:
PMC1481635
DOI:
10.1186/1743-422X-3-39
[Indexed for MEDLINE]
Free PMC Article

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