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Curr Opin Investig Drugs. 2006 May;7(5):443-50.

Autophagy: A protective mechanism in response to stress and inflammation.

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1
INSERM, Eri 7, Nantes F-44035, France. dominique.heymann@univ-nantes.fr

Abstract

Autophagy is one of the intracellular systems that is responsible for protein trafficking (degradation/recycling) in eukaryotic cells. This ubiquitous process contributes to cytosolic homeostasis, but its deregulation is often associated with various pathologies, including neurodegenerative diseases and cancer and pathologies with an altered inflammatory response. This review provides an overview of autophagy and discusses its regulation, function and future therapeutic possibilities, with a focus on the role of autophagy in inflammation.

PMID:
16729721
PMCID:
PMC3425450
[Indexed for MEDLINE]
Free PMC Article
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