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Ann Rheum Dis. 2007 Mar;66(3):283-92. Epub 2006 May 25.

Development of comprehensive disease assessment in systemic vasculitis.

Author information

1
Botnar Research Centre, University of Oxford, Oxford, UK.

Abstract

The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This article reviews and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis and reports ongoing initiatives for further development of disease assessment tools. A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and prognosis. The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic irreversible damage and impairment of function.

PMID:
16728460
PMCID:
PMC1855994
DOI:
10.1136/ard.2005.051078
[Indexed for MEDLINE]
Free PMC Article

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