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Semin Cancer Biol. 2006 Jun;16(3):203-13. Epub 2006 Apr 1.

14-3-3 proteins as potential oncogenes.

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Karmanos Cancer Institute and Department of Pathology, Wayne State University, Detroit, MI 48201, USA.


14-3-3 proteins are a family of highly conserved cellular proteins that play key roles in the regulation of central physiological pathways. More than 200 14-3-3 target proteins have been identified, including proteins involved in mitogenic and cell survival signaling, cell cycle control and apoptotic cell death. Importantly, the involvement of 14-3-3 proteins in the regulation of various oncogenes and tumor suppressor genes points to a potential role in human cancer. The present review summarizes current findings implicating a 14-3-3 role in cancer while discussing potential mechanisms and points of action of 14-3-3 during cancer development and progression.

[Indexed for MEDLINE]

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