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Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. Epub 2006 May 24.

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.

Author information

1
Drug Discovery, Valeant Pharmaceutical Research and Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. vchamakura@valeant.com

Abstract

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors.

PMID:
16725322
DOI:
10.1016/j.bmcl.2006.05.019
[Indexed for MEDLINE]

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