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Bioorg Med Chem Lett. 2006 Aug 1;16(15):4085-9. Epub 2006 May 24.

Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors.

Author information

1
Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA. david.sperandio@gilead.com

Abstract

The synthesis of novel [1,2,4]oxadiazoles and their structure-activity relationship (SAR) for the inhibition of tryptase and related serine proteases is presented. Elaboration of the P'-side afforded potent, selective, and orally bioavailable tryptase inhibitors.

PMID:
16725321
DOI:
10.1016/j.bmcl.2006.04.088
[Indexed for MEDLINE]

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