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Biochim Biophys Acta. 2006 May-Jun;1757(5-6):459-66. Epub 2006 Mar 6.

The physiological regulation of uncoupling proteins.

Author information

1
Buck Institute for Age Research, Mitochondrial Physiology, Novato, CA 94945, USA. dnicholls@buckinstitute.org

Abstract

Despite the enormous interest in the roles of novel uncoupling proteins, there is still great uncertainty as to their mechanism and regulation. The regulation of the architypal uncoupling protein 1 from brown adipose tissue was elucidated more than 20 years ago. This review suggests that a number of the approaches and criteria developed for the study of UCP1 could with profit be applied to current investigations of the novel UCPs.

PMID:
16725104
DOI:
10.1016/j.bbabio.2006.02.005
[Indexed for MEDLINE]
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