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Nature. 2006 May 25;441(7092):451-6.

Validating cancer drug targets.

Author information

1
Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Abstract

A cancer drug target is only truly validated by demonstrating that a given therapeutic agent is clinically effective and acts through the target against which it was designed. Nevertheless, it is desirable to declare an early-stage drug target as 'validated' before investing in a full-scale drug discovery programme dedicated to it. Although the outcome of validation studies can guide cancer research programmes, strictly defined universal validation criteria have not been established.

PMID:
16724057
DOI:
10.1038/nature04873
[Indexed for MEDLINE]

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