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Nat Rev Mol Cell Biol. 2006 Jun;7(6):391-403.

Interpreting the protein language using proteomics.

Author information

1
Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark. jenseno@bmb.sdu.dk

Abstract

Post-translational modifications define the functional and structural plasticity of proteins in archaea, prokaryotes and eukaryotes. Multi-site protein modification modulates protein activity and macromolecular interactions and is involved in a range of fundamental molecular processes. Combining state-of-the-art technologies in molecular cell biology, protein mass spectrometry and bioinformatics, it is now feasible to discover and study the structural and functional roles of distinct protein post-translational modifications.

PMID:
16723975
DOI:
10.1038/nrm1939
[Indexed for MEDLINE]

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