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Lancet. 1991 Mar 30;337(8744):762-3.

Severe limb abnormalities after chorion villus sampling at 56-66 days' gestation.

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  • 1Department of Medical Genetics, Churchill Hospital, Oxford, UK.


Among 289 pregnancies in which chorion villus sampling (CVS) was carried out at 56-66 days' gestation, 5 babies with severe limb abnormalities were subsequently identified. 4 had oromandibular-limb hypogenesis syndromes, and the other had a terminal transverse limb reduction defect. This high incidence raises the possibility that CVS was an aetiological factor for these developmental anomalies.

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