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Trends Mol Med. 2006 Jul;12(7):293-7. Epub 2006 May 24.

The Nogo receptor complex: confining molecules to molecular mechanisms.

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CNRS 7102, Equipe Développement Neuronal, Université Pierre et Marie Curie, 75005 Paris, France.


Myelin inhibitory ligands of the Nogo-66 receptor (NgR1) limit axon regeneration in the adult CNS. Recent findings have identified additional co-receptors (functional homologues) of the trimeric NgR1 complex, post-translational modifications of the co-receptors within the cell membrane and novel Ca(2+)-dependent cytoplasmic-protein phosphorylation mechanisms. Such unique signalling pathways provide the potential to transduce myelin-derived growth inhibitory signals to the axonal cytoskeleton, and have been areas of intense investigation in recent years. Here, we summarize current understanding of the molecular basis of myelin-derived axon-growth inhibition in the CNS.

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