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J Med Chem. 2006 Jun 1;49(11):3056-9.

Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness.

Author information

1
Johnson & Johnson Pharmaceutical Research & Development LLC, 1000 Route 202, Raritan, New Jersey 08869, USA.

Abstract

A novel SERM (selective estrogen receptor modulators), 1-(R), a chromene-derived bisbenzopyran, was discovered to alleviate hot flushes and effectively increase vaginal fluidity in rats. Moreover, 1-(R) was found to have beneficial effects on plasma cholesterol and bone metabolism while maintaining antiestrogenic activity in the uterus. The biological profile of its enantiomer 1-(S) was also evaluated.

PMID:
16722623
DOI:
10.1021/jm060353u
[Indexed for MEDLINE]

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