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Br J Cancer. 1991 Mar;63(3):447-50.

The long term prognostic significance of c-erbB-2 in primary breast cancer.

Author information

1
University Department of Surgery, Liverpool, UK.

Abstract

The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.

PMID:
1672256
PMCID:
PMC1971845
DOI:
10.1038/bjc.1991.103
[Indexed for MEDLINE]
Free PMC Article

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