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Liver Transpl. 2006 Jun;12(6):989-92.

Fulminant hepatic failure associated with the use of black cohosh: a case report.

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  • 1Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA.


With data from the Women's Health Initiative indicating that estrogen plus progesterone are associated with an increased risk of cardiovascular events, many patients and practitioners are looking for alternative therapies to manage menopausal symptoms. One alternative is black cohosh, an herbal product used primarily to treat these symptoms. In recent years there have been several case reports associating this substance with hepatitis and fulminant hepatic failure. We present a case of a woman who developed hepatic failure requiring liver transplantation from the use of this herb.

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