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Bioinformatics. 2006 Aug 1;22(15):1928-9. Epub 2006 May 23.

SNPStats: a web tool for the analysis of association studies.

Author information

1
Catalan Institute of Oncology, IDIBELL, Epidemiology and Cancer Registry L'Hospitalet, Barcelona, Spain.

Abstract

SUMMARY:

A web-based application has been designed from a genetic epidemiology point of view to analyze association studies. Main capabilities include descriptive analysis, test for Hardy-Weinberg equilibrium and linkage disequilibrium. Analysis of association is based on linear or logistic regression according to the response variable (quantitative or binary disease status, respectively). Analysis of single SNPs: multiple inheritance models (co-dominant, dominant, recessive, over-dominant and log-additive), and analysis of interactions (gene-gene or gene-environment). Analysis of multiple SNPs: haplotype frequency estimation, analysis of association of haplotypes with the response, including analysis of interactions.

AVAILABILITY:

http://bioinfo.iconcologia.net/SNPstats. Source code for local installation is available under GNU license.

PMID:
16720584
DOI:
10.1093/bioinformatics/btl268
[Indexed for MEDLINE]

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