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Lancet. 1991 Mar 16;337(8742):645-6.

Stimulation of lymphocyte natural cytotoxicity by L-arginine.

Author information

1
Department of Surgery, University of Aberdeen, UK.

Abstract

In vitro L-arginine enhanced natural-killer (NK) and lymphokine-activated-killer (LAK) cell activity; this cytotoxicity was mediated by CD56+ cells. In vivo arginine supplements (30 g/day for 3 days) increased the number of circulating CD56+ cells by a median of 32% in eight volunteers (p less than 0.01); this increase was associated with a mean rise of 91% in NK cell activity (p = 0.003) and of 58% in LAK cell activity (p = 0.001) in thirteen volunteers. These findings have potentially important implications for the modulation of natural cytotoxicity in a wide range of disease states.

PMID:
1671995
DOI:
10.1016/0140-6736(91)92456-c
[Indexed for MEDLINE]

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