Format

Send to

Choose Destination
World J Gastroenterol. 2006 May 21;12(19):2991-9.

Helicobacter pylori infection causes gastric cancer? A review of the epidemiological, meta-analytic, and experimental evidence.

Author information

1
School of Public Health, The University of Sydney, Sydney, New South Wales, Australia. eslickg@med.usyd.edu.au

Abstract

Since the discovery of Campylobacter-like organisms Helicobacter pylori (H pylori) more than two decades ago the possibility of a relationship with gastric cancer has been postulated, tested and supposedly proven. There have been numerous human studies of various designs from many countries around the world. Several meta-analyses have been published and more recently a small number of experimental animal studies were reported looking at the association between H pylori infection and gastric cancer. Over the years, the human epidemiological studies have produced conflicting results; the meta-analyses have as one would expect produced similar pooled estimates; while the early experimental animal studies require replication. The exact mechanisms by which H pylori might cause gastric cancer are still under investigation and remain to be elucidated.

PMID:
16718777
PMCID:
PMC4124371
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
Loading ...
Support Center