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Neurosci Lett. 2006 Jul 31;403(1-2):35-9. Epub 2006 May 23.

Expression of GABAA receptor beta2/3 subunits in the rat major pelvic ganglion.

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1
Department of Anatomy, Institute of Basic Medical Science and Industry-Academic Cooperation Foundation, Yonsei University Wonju College of Medicine, 162, Ilsan-dong, Gangwon-do 220-701, South Korea.

Abstract

Several pharmacological and physiological studies have suggested that GABA(A) receptors (GABA(A) Rs) may exist in the rat major pelvic ganglion (MPG), a large coalescent pelvic ganglion that contains both sympathetic and parasympathetic components which innervates pelvic organs. However, the presence of GABA(A) R in the MPG has never been demonstrated directly by morphological studies. In the present study, we used immunohistochemistry to demonstrate the existence of GABA(A) R beta2/3 subunits for the first time in the rat MPG. We also analyzed the neurochemical properties of MPG neurons expressing GABA(A) R beta2/3 subunits. GABA(A) R beta2/3-immunoreactive (-IR) neurons occupied 27.4+/-7.0% of the whole neuronal population, and many of these (77.6%) were co-localized with tyrosine hydroxylase (TH). Likewise, most (86.5%) of TH-IR neurons were GABA(A) R beta2/3-positive. GABA(A) R beta2/3 subunits were also expressed in a few VIP- or NOS-IR neurons, the cholinergic or non-adrenergic, non-cholinergic (NANC) neurons. These results suggest that GABA(A) Rs are involved in the modulation of most sympathetic, noradrenergic neurons and also a subset of VIP and NOS neurons of the rat MPG.

PMID:
16716506
DOI:
10.1016/j.neulet.2006.04.051
[Indexed for MEDLINE]
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