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Fertil Steril. 2006 Jul;86(1):230-2. Epub 2006 May 23.

Effects of short-term and long-term metformin treatment on menstrual cyclicity in women with polycystic ovary syndrome.

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Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298-0111, USA.


The purpose of this retrospective study was to compare the frequency of menstrual cyclicity between two groups of patients with polycystic ovary syndrome: women who were followed while on metformin for 3-6 months and those who were followed for >6 months. The results showed that metformin is highly effective in normalizing menstrual cyclicity in women with polycystic ovary syndrome (the overall response rate was 69%, with 88% of responders achieving normal cyclicity), especially with a treatment duration of 6 months or longer (the response rate was 40% higher for women who were treated with metformin for >6 months vs. 3-6 months, 77% vs. 55%).

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