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FEBS Lett. 2006 Jun 12;580(14):3462-8. Epub 2006 May 15.

CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation.

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Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Japan.


Neurotrophic factors are essential for the survival of neurons. We found that the endoplasmic reticulum (ER) stress-C/EBP homologues protein (CHOP) pathway to be activated during neurotrophic factor deprivation-induced apoptosis in PC12 neuronal cells and in primary cultured neurons, and this apoptosis was suppressed in the neurons from chop(-/-) mice. In addition, we found that CHOP is expressed in the subventricular zone (SVZ) and striatum of the young adult mouse brain. The number of apoptotic cells in the SVZ decreased in chop(-/-) mice. These results indicate that the ER stress-CHOP pathway plays a role in neuronal apoptosis during the development of the brain.

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