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Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21.

X-ray structure of influenza virus NS1 effector domain.

Author information

1
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Abstract

The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains.

PMID:
16715094
DOI:
10.1038/nsmb1099
[Indexed for MEDLINE]

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