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Nat Neurosci. 2006 Jun;9(6):732-4. Epub 2006 May 21.

Impaired light masking in dopamine D2 receptor-null mice.

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1
Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries 67404, Illkirch, Strasbourg, France.

Abstract

Disruption of overt circadian rhythms can occur without influencing the endogenous pacemaker, the so-called 'masking' effect classically elicited by light. As the physiological pathways involved in light masking remain elusive, we analyzed mice lacking the dopamine D2 receptor. Although circadian rhythmicity was normal, D2R-null mice showed a markedly deficient light masking response, indicating that D2R-mediated signaling is an essential component of the neuronal pathways leading to light masking of circadian rhythms.

PMID:
16715079
DOI:
10.1038/nn1711
[Indexed for MEDLINE]
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