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Nat Struct Mol Biol. 2006 Apr;13(4):305-10.

Determinants of histone H1 mobility and chromatin binding in living cells.

Author information

1
Protein Section, Laboratory of Metabolism, National Cancer Institute (NCI), US National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

The dynamic interaction of chromatin-binding proteins with their nucleosome binding sites is an important element in regulating the structure and function of chromatin in living cells. Here we review the major factors regulating the intranuclear mobility and chromatin binding of the linker histone H1, the most abundant family of nucleosome-binding proteins. The information available reveals that multiple and diverse factors modulate the interaction of H1 with chromatin at both a local and global level. This multifaceted mode of modulating the interaction of H1 with nucleosomes is part of the mechanism that regulates the dynamics of the chromatin fiber in living cells.

PMID:
16715048
PMCID:
PMC3730444
DOI:
10.1038/nsmb1077
[Indexed for MEDLINE]
Free PMC Article

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