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Mol Cell. 2006 May 19;22(4):436-7.

Autophagy by ARF: a short story.

Author information

1
Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Abstract

In this issue of Molecular Cell, Reef et al. (2006) describe a shortened unstable form of the ARF tumor suppressor protein that localizes within mitochondria, where it reduces membrane potential and triggers autophagy. Could this account for the Mdm2- and p53-independent tumor suppressive effects of ARF?

PMID:
16713573
DOI:
10.1016/j.molcel.2006.05.005
[Indexed for MEDLINE]
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