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Cell. 2006 May 19;125(4):651-4.

The exosome and the proteasome: nano-compartments for degradation.

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1
European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

Abstract

Exosomes and proteasomes are macromolecular complexes that posttranscriptionally regulate gene expression by degrading mRNAs and proteins, respectively. Although the two complexes act on different substrates and are composed of different subunits, they share a similar barrel-like architecture that appears to have evolved to restrict substrate access and prevent indiscriminate degradation.

PMID:
16713559
DOI:
10.1016/j.cell.2006.05.002
[Indexed for MEDLINE]
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