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J Clin Epidemiol. 2006 Jun;59(6):567-9.

A review finds that the autoreply e-mail function avoids problems of subject allocation concealment.

Author information

1
Department of Allied Health Professions, Faculty of Health, University of Central Lancashire, PR 1 2HE United Kingdom. acunningham@uclan.ac.uk

Abstract

BACKGROUND AND OBJECTIVES:

Using the autoreply e-mail function to avoid problems of subject allocation concealment.

METHODS:

A narrative review discussing technologic and methodologic issues in using autoreply e-mail to securely conceal subject allocation in randomized control trials.

RESULTS:

Autoreply e-mail can be successfully used to securely conceal subjects in a variety of randomized control trials.

CONCLUSIONS:

The allocation of subjects to intervention groups in randomized controlled trials should be achieved using methods that avoid both systematic bias and subject allocation transparency. The use of computer-generated tables and the automatic e-mail reply system are suggested as a solution to ensuring subject allocation concealment.

PMID:
16713518
DOI:
10.1016/j.jclinepi.2005.06.012
[Indexed for MEDLINE]

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