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J Paediatr Child Health. 2006 May;42(5):316-8.

Subcutaneous fat necrosis of the newborn: be aware of hypercalcaemia.

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  • 1Institute of Dermatology, University Hospital G. Martino, Messina, Italy.


Subcutaneous fat necrosis of the newborn is an uncommon, self-limiting panniculitis that usually occurs in full-term infants as a consequence of perinatal asphyxia. The cutaneous involvement may be associated with metabolic complications such as hypoglycaemia, thrombocytopenia, hypertriglyceridemia, anemia and hypercalcaemia. The delayed onset of hypercalcaemia, 1-6 months after the development of the skin manifestations, imposes a prolonged follow-up to avoid its acute toxic effects on cardiovascular and renal systems and the more durable metastatic calcifications.

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