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Lancet. 1991 Feb 2;337(8736):260-2.

Mortality in hereditary antithrombin-III deficiency--1830 to 1989.

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Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands.


To determine whether antithrombin-III (AT-III) deficiency leads to an excess mortality, we studied 171 individuals from ten families with a proven hereditary deficiency. 73 were classified as certainly deficient either by direct measurement of AT-III concentration or by mendelian inheritance patterns. 98 individuals had a high probability (0.5) of deficiency. The 64 deaths recorded did not exceed those expected for the general population adjusted for age, sex, and calendar period. We suggest that a policy of prophylactic anticoagulation for patients with AT-III deficiency cannot be recommended.

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