Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Microbiol. 2006 Jun;4(6):435-44.

Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus.

Author information

  • 1Georgetown University Medical Center, Department of Microbiology & Immunology, Washington, DC 20057, USA.

Abstract

Candida species and Aspergillus fumigatus were once thought to be relatively benign organisms. However, it is now known that this is not the case - Candida species rank among the top four causes of nosocomial infectious diseases in humans and A. fumigatus is the most deadly mould, often having a 90% mortality rate in immunocompromised transplant recipients. Adaptation to stress, including oxidative stress, is a necessary requisite for survival of these organisms during infection. Here, we describe the latest information on the signalling pathways and target proteins that contribute to oxidant adaptation in C. albicans and A. fumigatus, which has been obtained primarily through the analysis of mutants or inference from genome annotation.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk