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Clin Chem. 2006 Jul;52(7):1247-53. Epub 2006 May 18.

Gc-globulin: roles in response to injury.

Author information

1
Institute of Clinical Chemistry and Pathobiochemistry and Central Laboratory, Rheinisch-Westfälische Technische Hochschule (RWTH)-University Hospital Aachen, Aachen, Germany. umeier@ukaachen.de

Abstract

BACKGROUND:

Gc-globulin (vitamin D-binding protein) appears to have important functions in addition to its role as a carrier of vitamin D.

APPROACH:

We reviewed recent studies focusing on the pathophysiologic functions and clinical significance of Gc-globulin.

RESULTS:

Serum concentrations of Gc-globulin, as determined by immunoassay techniques, are decreased in severe injury. The extent of the decrease may have prognostic significance for patient outcomes. Clinical studies and animal models have shown that Gc-globulin has an important role in the clearance of procoagulant actin from the circulation after its release during cell necrosis and tissue injury. Gc-globulin has other potential roles in responses to acute tissue injury through conversion to a macrophage-activating factor, neutrophil chemotactic activity, and enhancement of C5a-mediated signaling.

CONCLUSION:

Considering the important physiologic roles of Gc-globulin in responses to tissue injury, such as clearance of actin, measurement of Gc-globulin may have value in directing the care of patients in many clinical disorders.

PMID:
16709624
DOI:
10.1373/clinchem.2005.065680
[Indexed for MEDLINE]
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