Efficient and practical synthesis of (R)-2-methylpyrrolidine

J Org Chem. 2006 May 26;71(11):4336-8. doi: 10.1021/jo060319n.

Abstract

An efficient, practical, and high yielding synthesis of (R)-2-methylpyrrolidine is described. The sequence allows for the scalable preparation of the target compound in just four synthetic steps and proceeds in 83% overall yield and >99% optical purity from readily available starting materials.

MeSH terms

  • Molecular Biology
  • Pyrrolidines / chemical synthesis*

Substances

  • 2-methylpyrrolidine
  • Pyrrolidines