Format

Send to

Choose Destination
Expert Opin Ther Targets. 2006 Jun;10(3):363-76.

Regeneration following spinal cord injury, from experimental models to humans: where are we?

Author information

1
Laboratory for NeuroRegeneration and Repair, University of Tuebingen, Hertie-Institute for Clinical Brain Research, D-72076 Tuebingen, Germany. simone.digiovanni@medizin.uni-tuebingen.de

Abstract

Regeneration in the adult CNS following injury is extremely limited. Traumatic spinal cord injury causes a permanent neurological deficit followed by a very limited recovery due to failed regeneration attempts. In fact, it is now clear that the spinal cord intrinsically has the potential to regenerate, but cellular loss and the presence of an inhibitory environment strongly limit tissue regeneration and functional recovery. The molecular mechanisms responsible for failed regeneration are starting to be unveiled. This gain in knowledge led to the design of therapeutic strategies aimed to limit the tissue scar, to enhance the proregeneration versus the inhibitory environment, and to replace tissue loss, including the use of stem cells. They have been very successful in several animal models, although results are still controversial in humans. Nonetheless, novel experimental approaches hold great promise for use in humans.

PMID:
16706677
DOI:
10.1517/14728222.10.3.363
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center