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Curr Opin Neurobiol. 2006 Jun;16(3):251-7. Epub 2006 May 15.

Homer proteins: implications for neuropsychiatric disorders.

Author information

1
Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA, 93106-9660, USA. szumlinski@psych.ucsb.edu

Abstract

Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.

PMID:
16704932
DOI:
10.1016/j.conb.2006.05.002
[Indexed for MEDLINE]

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