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Emerg Infect Dis. 2006 May;12(5):775-9.

Coronavirus HKU1 infection in the United States.

Author information

1
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Abstract

In 2005, a new human coronavirus, HCoV-HKU1, was identified in Hong Kong. We screened respiratory specimens collected from December 16, 2001, to December 15, 2002, from children <5 years of age who tested negative for respiratory syncytial virus, parainfluenza viruses, influenza virus, and adenovirus for HCoV-HKU1 by reverse transcription-polymerase chain reaction. Overall, 1,048 respiratory specimens from 851 children were tested, and 9 HCoV-HKU1-positive children (1%) were identified, 2 of whom had 2 positive specimens. Children who had HCoV-HKU1 infection had evidence of either upper or lower respiratory tract infection or both. Two patients had disease beyond the respiratory tract. HCoV-HKU1 was identified from December 2001 to February 2002. Sequence analyses suggest that a single strain was circulating. HCoV-HKU1 is therefore likely circulating in the United States and is associated with upper and lower respiratory tract disease.

PMID:
16704837
PMCID:
PMC3374449
DOI:
10.3201/eid1205.051316
[Indexed for MEDLINE]
Free PMC Article

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