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J Invest Dermatol. 2006 Jun;126(6):1214-6.

Genomic instability and tumor stem cells.

Author information

1
Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. grich001@mc.duke.edu

Abstract

Wang et al. point to the existance of a common progenitor tumor stem cell that gives rise to genomically unstable progeny in malignant melanoma. Although it is not known what creates this genomic instability, given the presence of testis antigens in melanoma, it is tempting to speculate that it is caused by a collision of meiotic and mitotic pathways.

PMID:
16702970
DOI:
10.1038/sj.jid.5700240
[Indexed for MEDLINE]
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