Format

Send to

Choose Destination
Ann Intern Med. 2006 May 16;144(10):735-41.

Brief communication: Glomerulonephritis in patients with hepatitis C cirrhosis undergoing liver transplantation.

Author information

1
University of Alabama at Birmingham, Birmingham, Alabama 35294-0005, USA. bmcguire@uab.edu

Abstract

BACKGROUND:

Patients infected with hepatitis C virus (HCV) frequently develop renal failure after liver transplantation.

OBJECTIVE:

To describe renal histologic characteristics and concomitant clinical features in HCV-infected patients with end-stage cirrhosis.

DESIGN:

Case series.

SETTING:

Single-center liver transplant program in the United States.

PATIENTS:

30 patients who received liver transplants for HCV-induced cirrhosis.

INTERVENTION:

Kidney biopsy during liver engraftment.

MEASUREMENTS:

Clinical data and laboratory tests of renal function within 6 months before liver transplantation.

RESULTS:

Twenty-five patients had immune-complex glomerulonephritis: membranoproliferative glomerulonephritis type 1 (n = 12), IgA nephropathy (n = 7), and mesangial glomerulonephritis (n = 6). Of these patients, 10 had normal serum creatinine levels, normal urinalysis results, and normal quantitative proteinuria. For 5 others, the only renal abnormality was an increased serum creatinine level. No patient had cryoglobulins in the blood or kidney.

LIMITATIONS:

This small observational study did not include patients with nonviral cirrhosis and did not document post-transplantation outcomes.

CONCLUSIONS:

Immune-complex glomerulonephritis was common in patients with end-stage HCV-induced cirrhosis and was often clinically silent. Its potential to cause renal failure after liver transplantation may be underappreciated.

Comment in

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center