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J Cutan Med Surg. 2005 Dec;9(6):289-95.

Molecular aspects of ultraviolet radiation-induced apoptosis in the skin.

Author information

1
Department of Laboratory Medicine and Pathology, 4B1.19 Walter C Mackenzie Health Science Centre, University of Alberta, Edmonton, AB, Canada.

Abstract

BACKGROUND:

Apoptosis, or programmed cell death, is an essential physiological process that controls cell numbers during physiological processes, and eliminates abnormal cells that can potentially harm an organism.

OBJECTIVE:

This review summarizes our current state of knowledge of apoptosis induction in skin by UV radiation.

METHODS:

A review of the literature was undertaken focusing on cell death in the skin secondary to UV radiation.

RESULTS:

It is evident that a number of apoptotic pathways, both intrinsic and extrinsic, are induced following exposure to damaging UV radiation.

CONCLUSION:

Although our understanding of the apoptotic processes is gradually increasing, many important aspects remain obscure. These include interconnections between pathways, wavelength-specific differences and cell type differences.

PMID:
16699907
DOI:
10.1177/120347540500900604
[Indexed for MEDLINE]

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