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Cell Mol Life Sci. 2006 Aug;63(16):1823-32.

The cellular functions of clathrin.

Author information

1
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom. sjr51@mrc-lmb.cam.ac.uk

Abstract

Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin lattice and discovery of a new function for clathrin that occurs during mitosis.

PMID:
16699812
PMCID:
PMC3475309
DOI:
10.1007/s00018-005-5587-0
[Indexed for MEDLINE]
Free PMC Article

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