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Plant Cell Physiol. 2006 Jul;47(7):1004-9. Epub 2006 May 13.

n-Butanol induces depolymerization of microtubules in vivo and in vitro.

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Graduate School of Life Science, University of Hyogo, Japan.


The effects of butanol on microtubules (MTs) were examined by immunofluorescence microscopy. Fragmentation of cortical MTs was induced by n-butanol, but not by s- and t-butanols, in cultured tobacco BY-2 cells. Taxol prevented n-butanol-induced MT fragmentation. Fragmented cortical MTs were still attached to the inner face of the plasma membrane when n-butanol-treated protoplasts were ruptured on the slide glass. Moreover, MTs were depolymerized in the presence of n-butanol in vitro. Therefore, n-butanol is not only an activator of phospholipase D but also an effective MT-depolymerizing agent.

[Indexed for MEDLINE]

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