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Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1179-89. Epub 2006 Apr 7.

Mitochondrial DNA transcription and diseases: past, present and future.

Author information

1
Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza-Instituto Aragonés de Ciencias de la Salud, Miguel Servet 177, 50013-Zaragoza, Spain. jmontoya@unizar.es

Abstract

The transcription of mitochondrial DNA has been studied for 30 years. However, many of the earlier observations are still unsolved. In this review we will recall the basis of mitochondrial DNA transcription, established more than twenty years ago, will include some of the recent progress in the understanding of this process and will suggest hypotheses for some of the unexplained topics. Moreover, we will show some examples of mitochondrial pathology due to altered transcription and RNA metabolism.

PMID:
16697348
DOI:
10.1016/j.bbabio.2006.03.023
[Indexed for MEDLINE]
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