Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8. Epub 2006 May 11.

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.

Author information

1
Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. rburli@amgen.com

Abstract

We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 microM concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration.

PMID:
16697190
DOI:
10.1016/j.bmcl.2006.04.068
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center