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Pathol Biol (Paris). 2007 Feb;55(1):37-48. Epub 2006 May 11.

Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes.

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1
Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden. kajsa.paulsson@med.lu.se

Abstract

Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and 10% of the cytogenetically abnormal cases, respectively. However, despite the high frequency of +8, much remains to be elucidated as regards its epidemiology, etiology, clinical impact, association with other chromosomal abnormalities, cell of origin, and functional and pathogenetic consequences. Here, we summarize and review these various aspects of trisomy 8, focusing on AMLs and MDS harboring this abnormality as a single change.

PMID:
16697122
DOI:
10.1016/j.patbio.2006.04.007
[Indexed for MEDLINE]
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